This is a database of peer-reviewed literature that focuses on Genetic Biocontrol research. The latest are shown here.
Role of CRISPR Technology in Gene Editing of Emerging and Re-emerging Vector Borne Disease
Background
Vector borne diseases are rampant across the world. Due to spread and establishment of vector species in different geographical areas, vector adaptation and resistance towards many insecticides the only option left is vector control for various vector borne diseases. Recent advancement in the field of genome editing have provided a variety of tools like, CRISPR, a novel genome editing techniques which can be applied for the control and prevention of many deadly diseases like dengue, chikungunya, filariasis, Japanese encephalitis and Zika.
Mahto, K. K., Prasad, P., Kumar, M., Dubey, H., & Ranjan, A. (2022). Role of CRISPR Technology in Gene Editing of Emerging and Re-emerging Vector Borne Disease. In Mosquito Research-Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies. IntechOpen.
Modelling homing suppression gene drive in haplodiploid organisms
Gene drives have shown great promise for suppression of pest populations. These engineered alleles can function by a variety of mechanisms, but the most common is the CRISPR homing drive, which converts wild-type alleles to drive alleles in the germline of heterozygotes. Some potential target species are haplodiploid, in which males develop from unfertilized eggs and thus have only one copy of each chromosome. This prevents drive conversion, a substantial disadvantage compared to diploids where drive conversion can take place in both sexes. Here, we study homing suppression gene drives in haplodiploids and find that a drive targeting a female fertility gene could still be successful.
Liu, Y., & Champer, J. (2022). Modelling homing suppression gene drive in haplodiploid organisms. Proceedings of the Royal Society B, 289(1972), 20220320.