Overexpression of multiple cytochrome P450 genes with and without knockdown resistance mutations confers high resistance to deltamethrin in Culex quinquefasciatus

The cytochrome P450s-mediated metabolic resistance and the target site insensitivity caused by the knockdown resistance (kdr) mutation in the voltage-gated sodium channel (vgsc) gene were the main mechanisms conferring resistance to deltamethrin in Culex quinquefasciatus from Thailand. This study aimed to investigate the expression levels of cytochrome P450 genes and detect mutations of the vgsc gene in deltamethrin-resistant Cx. quinquefasciatus populations in Thailand.

Chamnanya, S., Kiddela, B., Saingamsook, J., Nachaiwieng, W., Lumjuan, N., Somboon, P., & Yanola, J. (2025). Overexpression of multiple cytochrome P450 genes with and without knockdown resistance mutations confers high resistance to deltamethrin in Culex quinquefasciatus. Infectious Diseases of Poverty, 14, 2. https://doi.org/10.1186/s40249-024-01269-2

Read More: https://doi.org/10.1186/s40249-024-01269-2