Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: A modeling study
Background
Wolbachia bacteria can be placed into insects and released into the wild, where the Wolbachia spreads throughout the insect population. They have been used as an effective disease control tool because the Wolbachia reduces transmission of pathogens by mosquitoes. It may also be possible to use the Wolbachia spread mechanism to power a gene drive, allowing for flexible deployment of cargo genes in insect populations.
Li, J., & Champer, J. (2023). Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: A modeling study. PLoS Genetics, 19(1), e1010591.