Genome editing of WSSV CRISPR/Cas9 and immune activation extends the survival of infected Penaeus vannamei

White spot syndrome virus (WSSV) is an exceptionally harmful virus that generally causes high levels of mortality in cultured shrimp. Attempts at viral suppression have been made to control the disease and have achieved limited efficiency. Recent advances in genome editing technology using CRISPR/Cas9 have led to potential innovations to prevent or treat many viral diseases. In this study, a CRISPR/Cas9 system was applied to WSSV genome cleavage to suppress WSSV infection in shrimp.

Pudgerd, A., Saedan, S., Santimanawong, W. et al. Genome editing of WSSV CRISPR/Cas9 and immune activation extends the survival of infected Penaeus vannamei. Sci Rep 14, 26306 (2024). https://doi.org/10.1038/s41598-024-78277-7

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